Very long ago, the veterinary surgeons have recognized that when the livestock and poultry feed trace of the mold toxin, although not cause obvious symptoms of poisoning, but it will cause immune suppression. The intake of small quantities of mycotoxins may lead to decreased immunity of pigs and infectious disease resistance weakened. Fungal toxin is mainly through the following four aspects of the immune system:

1 inhibition of protein synthesis and DNA synthesis: aflatoxin by binding with DNA and RNA to inhibit its synthesis, causing thymic dysplasia and atrophy, affecting the liver and macrophage function. Aflatoxin and trichothecenes mould olefinic toxin (T-2 and vomitoxin) can inhibit the synthesis of protein and DNA, T-2 toxin mainly role in cell division strong tissues and organs, such as liver, thymus, bone marrow, spleen, lymph nodes and other. The effects of vomiting toxin on the growth of the cells such as gastrointestinal mucosal cells, lymphocytes, thymus cells, spleen cells, bone marrow hematopoietic cells, etc..

2 reduce the cellular immunity and humoral immune function, aflatoxin is a strong immune suppression of the toxin, 25ug/L aflatoxin can cause animal immune function inhibition. The main effect of aflatoxin on cellular immunity. The in vitro experiment showed that aflatoxin could decrease the ability of macrophage to swallow the bacteria. Ochratoxin A can reduce the production of antibodies, affect the humoral immune and caused granulosa cell phagocytic function and cellular immunity decreased.

3. Induction of programmed cell death: mycotoxins by directly affect the key enzyme or by changing the balance between oxidation and antioxidant agents in cells, especially reduction of glutathione concentration, to stimulate the programmed cell death, caused by the contraction in the cell. Ochratoxin A can prevent the proliferation of lymphocytes in vitro, and lead to the apoptosis of lymphocytes. Vomiting toxin can also function in bone marrow hematopoietic stem cells to produce cytotoxicity, the role of T, B lymphocytes produce immune toxicity, induced programmed cell death.

4 indirect inhibition of immunity: fungal toxins can also indirectly suppress the immune system by other means. Such as T-2 activation of the endocrine system, in the stress state to promote the release of cortisol, indirectly suppress immune function. The vomiting toxin can indirectly suppress the immune system through neurotoxicity. The disorder of estrogen secretion caused by the corn, and the regulation of the function of the immune organ.

Measures of prevention and control of mycotoxins: 1. A good feed: pig farms should try to choose high-quality corn, for the light of moldy corn, pig farms can use corn peeling machine to preprocess the corn and corn peeling needs to add 1% fat powder.

2 the rational use of anti mildew agent, anti mildew agent should be added according to the routine, adding "moldy corn anti drug agents". Mainly because of drug enforcement agents adsorb mycotoxins, absorption spectrum and the adsorption of many kinds of mycotoxins, and does not have the interference to the nutrition.

3. To repair the damaged immune system: in view of the current serious harm of mycotoxins, despite taking various measures to prevent and control, or may will cause varying degrees of damage to the immune system from pigs, so should be regularly add Astragalus Polysaccharides on immune system damage to repair, add dose to 400 grams / ton, monthly lasted 10 days to ensure healthy and stable herd.

4. Make a feed store and trough periodic cleaning: on the one hand, many farmers to buy the raw materials, but because of improper storage will also lead to raw moldy, such as in the storage of raw materials at the bottom should placed thickening board to avoid moisture, rodents, insects etc. work is particularly important; on the other hand, livestock and poultry feed trough also need regular cleaning, if trough long-term clean-up, the backlog of feed extremely prone to mildew. This kind of detail problem is easy to be ignored by everyone. This article from "anti drug agents"